Treatment of chronic insomnia in elderly adults with dual orexin receptor antagonists: a systematic review and meta-analysis.

ABSTRACT:

Study objectives

Chronic insomnia is common among older adults, and its management is particularly challenging due to changes in sleep architecture, multimorbidity, and increased vulnerability to adverse drug effects. Dual orexin receptor antagonists have emerged as a novel therapeutic class with promising efficacy and tolerability profiles. However, evidence specific to older adults remains limited. Here, we performed the first systematic review and meta-analysis specifically evaluating the efficacy and safety of dual orexin receptor antagonists in elderly patients with chronic insomnia (PROSPERO CRD42024565687).

Methods

Randomized controlled trials were identified from MEDLINE, Scopus, and ClinicalTrials.gov. Objective polysomnographic outcomes, including latency to persis

SUBMITTER: Rollo E 

PROVIDER: S-EPMC13472891 | biostudies-literature | 2026 Aug

REPOSITORIES: biostudies-literature