LncRNA NRAV is associated with unfavorable prognosis and immune-related transcriptional features in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) remains a lethal malignancy, and robust biomarkers are needed to refine risk stratification and support clinical decision-making. Long noncoding RNAs can shape tumor biology and immune states. We investigated the clinical relevance of lncRNA NRAV in HCC and its association with immune-related features.

Methods

NRAV expression and clinical associations were assessed using TCGA-LIHC, paired tumor-adjacent tissue comparisons, GTEx normal liver controls, and independent GEO cohorts. Prognostic associations were evaluated by Kaplan-Meier and Cox regression analyses. Immune features were profiled using ssGSEA and correlation analyses with immune checkpoint molecules. Functional effects of NRAV were examined in HCC cells using loss-of-funct

SUBMITTER: Fang X 

PROVIDER: S-EPMC13473033 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature