Integrative Phenotypic and Transcriptomic Dynamics of Hair Follicle Development and Fur Quality in Rex Rabbits.

ABSTRACT: Rex rabbit fur quality determines economic value, yet the age-dependent dynamics of hair follicle development and their molecular drivers are largely unknown. Here, we performed a time-series integrative analysis combining phenotypic measurements, quantitative histomorphology, and transcriptome sequencing in Yongqing Rex rabbits across 1 to 6 months of age (10 rabbits per month). Fur thickness exhibited a pattern of increase, stabilization, and subsequent increase, with no significant differences between 2M and 4M (p > 0.05). Coat density peaked at 6M, with an average pelt area of 1358.20 ± 52.43 cm² at 5M and 6M. Fiber length increased and then plateaued, whereas hair diameter showed an increase-decrease-stabilization pattern. Histological analysis revealed a significant age-re

SUBMITTER: Cao C 

PROVIDER: S-EPMC13473066 | biostudies-literature | 2026 Aug

REPOSITORIES: biostudies-literature