Autologous cutis and subcutis micrografts combined with a collagen-elastin dermal scaffold for chronic wounds: a retrospective single-arm clinical study with prospectively collected data.

ABSTRACT:

Background

Chronic wounds remain a significant clinical challenge, characterised by sustained inflammation, impaired angiogenesis, and defective extracellular matrix remodelling. Autologous cutis and subcutis micrografts and collagen-elastin dermal scaffolds have each shown promise in wound healing, but their combination has not been previously investigated in a clinical study. This study aimed to evaluate the feasibility, safety, and preliminary effectiveness of autologous cutis and subcutis micrografts seeded onto a collagen-elastin dermal scaffold for the treatment of chronic wounds.

Methods

A single-arm, single-centre, retrospective analysis of prospectively collected data was conducted. Forty-four patients with chronic wounds were screened; 34 met the eligibility criter

SUBMITTER: Ioannidis O 

PROVIDER: S-EPMC13473281 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature