Two DNA invertases contribute to flagellar phase variation in Salmonella enterica serovar Typhimurium strain LT2.

ABSTRACT: Salmonella enterica serovar Typhimurium strain LT2 possesses two nonallelic structural genes, fliC and fljB, for flagellin, the component protein of flagellar filaments. Flagellar phase variation occurs by alternative expression of these two genes. This is controlled by the inversion of a DNA segment, called the H segment, containing the fljB promoter. H inversion occurs by site-specific recombination between inverted repetitious sequences flanking the H segment. This recombination has been shown in vivo and in vitro to be mediated by a DNA invertase, Hin, whose gene is located within the H segment. However, a search of the complete genomic sequence revealed that LT2 possesses another DNA invertase gene that is located adjacent to another invertible DNA segment within a resident prophage,

SUBMITTER: Kutsukake K 

PROVIDER: S-EPMC1347348 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature