A TriNetX global collaborative network retrospective cohort study on the impact of COVID-19 vaccination on juvenile idiopathic arthritis.

ABSTRACT: The objective is to determine the Impact of COVID-19 Vaccination and Medical Utilization in Juvenile Idiopathic Arthritis (JIA) patients. Our study retrieved data from the US Collaborative Network in TriNetX between January 1st, 2020, and June 30th, 2023. We investigated the incidence of COVID-19, medical utilization, and mortality in JIA patients. The HR and 95% CI of the outcomes were calculated between propensity score-matched (PSM) 1:1. 652 vaccinated and 652 unvaccinated JIA patients were enrolled. The vaccinated group demonstrated a significantly elevated risk of infection of COVID-19 but also a notably higher overall use of medical services, with a hazard ratio (HR) of 2.112 and a 95% confidence interval (C.I.) ranging from 1.081 to 4.129. No significant difference in the risk of ou

SUBMITTER: Yong SB 

PROVIDER: S-EPMC13473531 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature