Blood glucose trajectory phenotypes are associated with in-hospital mortality in a multicenter ICU stroke cohort.

ABSTRACT: Non-traumatic stroke (NTS) is associated with high mortality, and dynamic glucose patterns may provide prognostic information beyond static glucose measurements. This study aimed to identify glucose trajectory phenotypes in ICU patients with NTS and evaluate their association with in-hospital mortality. This multicenter retrospective cohort study included ICU patients with NTS from MIMIC-IV, eICU, and NSICU. Glucose trajectories during the first 168 h after ICU admission were identified using latent class growth modeling. Associations with in-hospital mortality were assessed using Cox regression, Kaplan-Meier analysis, competing-risk analysis, and subgroup analyses. Incremental predictive value was evaluated using AUC, integrated discrimination improvement (IDI), net reclassification impro

SUBMITTER: Wang J 

PROVIDER: S-EPMC13473554 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature