HuR-dependent expression of RyR2 contributes to calcium-mediated thermogenesis in murine brown adipocytes.

ABSTRACT: Several thermogenic pathways have been described in adipose tissue, including calcium-mediated thermogenesis in beige adipocytes. We have previously shown that adipocyte-specific deletion of the RNA binding protein human antigen R (HuR; Elavl1) results in thermogenic dysfunction. RNA sequencing revealed the downregulation of several calcium transport genes upon HuR deletion. The goal of this work was to define the HuR-dependent mechanisms of calcium driven thermogenesis in brown adipocytes. Brown adipose tissue (BAT)-specific HuR-deletion (BAT-HuR^-/-) mice have no changes in their body weight, glucose tolerance, adipose tissue weights, or lipid droplet size compared to control, but are cold intolerant following acute thermal challenge at 4 °C. We also found decreased expression

SUBMITTER: Guarnieri AR 

PROVIDER: S-EPMC13473574 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature