Curcumin-stabilized silver nanoparticles target the Helicobacter pylori-tumor interface in gastric cancer.

ABSTRACT: Gastric cancer remains a major global health burden, ranking among the leading causes of cancer-related mortality worldwide. Chronic infection with Helicobacter pylori is a well-established etiological factor, promoting sustained gastric inflammation, epithelial transformation, and tumor progression through modulation of the gastric microenvironment. Therapeutic strategies that simultaneously target microbial virulence and tumor cell survival remain limited. In this study, we developed curcumin-stabilized silver nanoparticles (AgNPs) as a dual-functional nanoformulation designed to modulate the tumor-associated microbiome while exerting direct anti-cancer effects. The nanoparticles were chemically synthesized with a controlled diameter of 15 ± 2 nm, enabling enhanced surface reactivity and

SUBMITTER: Attri K 

PROVIDER: S-EPMC13473628 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature