Flavonoids of Rosa sterilis S. D. Shi alleviate high-fat diet-induced hyperlipidemia in mice by activation of autophagy.

ABSTRACT: Obesity and hyperlipidemia are global health crises linked to metabolic disorders, characterized by an abnormal accumulation of triglycerides in fat cells. Autophagy, an essential cellular degradation mechanism, plays a key role in maintaining adipocyte balance and lipid metabolism. Recent studies have found that polysaccharides and the juice of Rosa sterilis S. D. Shi (RS) have hypolipidemic effects. However, the effects of flavonoids from RS (FRS) on lipid metabolism and their potential hypolipidemic and hypoglycemic roles remain unclear. Here, we found that FRS alleviated obesity symptoms and corrected glycolipid metabolism in mice induced by a high-fat diet. Further studies revealed that FRS reduced liver injury and fat accumulation, accompanied by counteracting oxidative stress in the

SUBMITTER: Wang JQ 

PROVIDER: S-EPMC13473673 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature