SCOPPI: a structural classification of protein-protein interfaces.

ABSTRACT: SCOPPI, the structural classification of protein-protein interfaces, is a comprehensive database that classifies and annotates domain interactions derived from all known protein structures. SCOPPI applies SCOP domain definitions and a distance criterion to determine inter-domain interfaces. Using a novel method based on multiple sequence and structural alignments of SCOP families, SCOPPI presents a comprehensive geometrical classification of domain interfaces. Various interface characteristics such as number, type and position of interacting amino acids, conservation, interface size, and permanent or transient nature of the interaction are further provided. Proteins in SCOPPI are annotated with Gene Ontology terms, and the ontology can be used to quickly browse SCOPPI. Screenshots are avai

SUBMITTER: Winter C 

PROVIDER: S-EPMC1347461 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature