Flexible Structural Neighborhood--a database of protein structural similarities and alignments.

ABSTRACT: Protein structures are flexible, changing their shapes not only upon substrate binding, but also during evolution as a collective effect of mutations, deletions and insertions. A new generation of protein structure comparison algorithms allows for such flexibility; they go beyond identifying the largest common part between two proteins and find hinge regions and patterns of flexibility in protein families. Here we present a Flexible Structural Neighborhood (FSN), a database of structural neighbors of proteins deposited in PDB as seen by a flexible protein structure alignment program FATCAT, developed previously in our group. The database, searchable by a protein PDB code, provides lists of proteins with statistically significant structural similarity and on lower menu levels provides detai

SUBMITTER: Li Z 

PROVIDER: S-EPMC1347486 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature