Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons.

ABSTRACT: The ability of neurons to alter their transcriptional programs in response to synaptic input is of fundamental importance to the neuroplastic mechanisms underlying learning and memory. Because of technical limitations of conventional gene detection methods, the current view of activity-dependent neural transcription derives from experiments in which neurons are assumed quiescent until a signaling stimulus is given. The present study was designed to move beyond this static model by examining how earlier episodes of neural activity influence transcription of the immediate-early gene Arc. Using a sensitive FISH method that detects primary transcript at genomic alleles, the proportion of hippocampal CA1 neurons that activate transcription of Arc RNA was constant at approximately 40% in respons

SUBMITTER: Guzowski JF 

PROVIDER: S-EPMC1347968 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature