Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus.

ABSTRACT: In adult primary visual cortex (V1), dendritic spines are more persistent than during development. Brain-derived neurotrophic factor (BDNF) increases synaptic strength, and its levels rise during cortical development. We therefore asked whether postsynaptic BDNF signaling through its receptor TrkB regulates spine persistence in adult V1. This question has been difficult to address because most methods used to alter TrkB signaling in vivo affect cortical development or cannot distinguish between pre- and postsynaptic mechanisms. We circumvented these problems by employing transgenic mice expressing a dominant negative TrkB-EGFP fusion protein in sparse pyramidal neurons of the adult neocortex and hippocampus, producing a Golgi-staining-like pattern. In adult V1, expression of dominant negat

SUBMITTER: Chakravarthy S 

PROVIDER: S-EPMC1347973 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature