YplA is exported by the Ysc, Ysa, and flagellar type III secretion systems of Yersinia enterocolitica.

ABSTRACT: Yersinia enterocolitica maintains three different pathways for type III protein secretion. Each pathway requires the activity of a specific multicomponent apparatus or type III secretion system (TTSS). Two of the TTSSs are categorized as contact-dependent systems which have been shown in a number of different symbiotic and pathogenic bacteria to influence interactions with host organisms by targeting effector proteins into the cytosol of eukaryotic cells. The third TTSS is required for the assembly of flagella and the secretion of the phospholipase YplA, which has been implicated in Y. enterocolitica virulence. In this study, YplA was expressed from a constitutive promoter in strains that contained only a single TTSS. It was determined that each of the three TTSSs is individually sufficien

SUBMITTER: Young BM 

PROVIDER: S-EPMC134849 | biostudies-literature | 2002 Mar

REPOSITORIES: biostudies-literature