Transcriptional response of Pasteurella multocida to nutrient limitation.

ABSTRACT: Bacteria often encounter environments where nutrient availability is limited, and they must adapt accordingly. To identify Pasteurella multocida genes that are differentially expressed during nutrient limitation, we utilized whole-genome microarrays to compare levels of gene expression during growth in rich and minimal media. Our analysis showed that the levels of expression of a total of 669 genes, representing approximately one-third of the genome, were detectably altered over the course of the experiment. A large number (n = 439) of genes, including those involved in energy metabolism, transport, protein synthesis, and binding, were expressed at higher levels in rich medium, suggesting that, upon exposure to a rich environment, P. multocida immediately begins to turn on many energy-inte

SUBMITTER: Paustian ML 

PROVIDER: S-EPMC135142 | biostudies-literature | 2002 Jul

REPOSITORIES: biostudies-literature