Toward cocaine esterase therapeutics.

ABSTRACT: Cocaine is among the most reinforcing of all drugs of abuse, yet no effective pharmacotherapy is available. Herein, we report the development and characterization of phage-displayed cocaine esterases with pharmacologically relevant kinetic parameters (kcat/Km approximately 104 M-1 s-1).

SUBMITTER: Rogers CJ 

PROVIDER: S-EPMC1352337 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature