Alcohol intake and risk of stomach cancer: a pooled analysis of 20 cohorts.

ABSTRACT:

Background

Stomach cancer presents complex etiological heterogeneity. Ethanol in alcoholic beverages and its metabolite acetaldehyde are carcinogens causally linked to several cancers, but their role in gastric carcinogenesis has not been established. We analyzed harmonized, individual-level prospective data to examine associations between alcohol intake and risk of stomach cancer and its subtypes.

Methods

In total, 2 009 951 participants in 20 cohorts (mean follow-up = 9 to 29 years) within the Pooling Project of Prospective Studies of Diet and Cancer (n = 8357 incident invasive gastric adenocarcinomas) were included. We used Cox regression to assess associations between alcohol intake and risk of stomach cancer overall and by anatomical and histological subtype and populat

SUBMITTER: Jayasekara H 

PROVIDER: S-EPMC13589573 | biostudies-literature | 2026 Sep

REPOSITORIES: biostudies-literature