Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine.

ABSTRACT: Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A combining with PERV-C-related sequences.

SUBMITTER: Oldmixon BA 

PROVIDER: S-EPMC135987 | biostudies-literature | 2002 Mar

REPOSITORIES: biostudies-literature