Tumor marker-responsive behavior of gels prepared by biomolecular imprinting.

ABSTRACT: We report dynamic glycoprotein recognition of gels prepared by biomolecular imprinting using lectin and antibody molecules as ligands for tumor-specific marker glycoproteins. The glycoprotein-imprinted gels prepared with minute amounts of cross-linkers could dynamically recognize tumor-specific marker glycoproteins by lectin and antibody ligands and induce volume changes according to the glycoprotein concentration. The glycoprotein-imprinted gel shrank in response to a target glycoprotein but nonimprinted gel swelled a little. The glycoprotein-responsive shrinking of the imprinted gel was caused by formation of lectin-glycoprotein-antibody complexes that acted as reversible cross-linking points. Glycoprotein-imprinted gels only shrank when both lectin and antibody in the gels simultaneousl

SUBMITTER: Miyata T 

PROVIDER: S-EPMC1360525 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature