Vespula spp. venom immunotherapy: basophil excitability and Fc_εRI/Fc_γRIIb expression.

ABSTRACT:

Background

Basophils are recognized as important effector cells during the sensitization and effector phases of IgE-mediated allergy. Besides histamine release during anaphylaxis, basophils contribute to early immune polarization as an important source of Th2-associated cytokines. Vespula spp. venom immunotherapy (VIT) represents a prime example of clinically highly effective allergen-specific immunotherapy. This study investigated functional and phenotypic changes in circulating basophils during early VIT in a homogenous case series.

Methods

Twenty-four patients eligible for VIT were examined before treatment, after 3 days, and after 1 month of therapy. Basophils were primed with interleukin-(IL-)3 and stimulated with IgE-dependent triggers, including Vespula spp. venom and

SUBMITTER: Fleissner J 

PROVIDER: S-EPMC13617696 | biostudies-literature | 2026 Sep

REPOSITORIES: biostudies-literature