The impact of statin therapy on amputation risk in patients with diabetic foot infection: a retrospective cohort study from Jordan.

ABSTRACT:

Background

Diabetic foot infection (DFI) is a major cause of non-traumatic lower-limb amputation and is associated with poor survival outcomes. Identifying therapies that reduce progression to amputation is critical.

Objective

To evaluate the association between statin therapy and risk of amputation in patients with DFI, including assessment of dose-response effects.

Methods

A retrospective cohort study involving 376 patients presenting with DFI at a university hospital in Jordan between January 2020 and April 2024. The primary outcome was amputation severity (no amputation, minor amputation, major amputation), analyzed using multivariable ordinal logistic regression, adjusting for potential confounders; major amputation incidence was also examined as a secondary bina

SUBMITTER: Abdallah J 

PROVIDER: S-EPMC13623674 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature