Correlation of tumor maximum standardized uptake value from ¹⁸F-BPA PET and boron neutron capture therapy tumor dose with treatment outcomes in head and neck cancer: a retrospective analysis.

ABSTRACT:

Purpose

Boron neutron capture therapy (BNCT) dose planning conventionally uses a tumor-to-blood (T/B) ratio derived from the tumor maximum standardized uptake value (SUVmax) of fluorine-18-labeled 4-borono-L-phenylalanine (¹⁸F-BPA) positron emission tomography (PET) (individual model). It remains unclear whether tumor SUVmax or individual model doses predict outcomes in accelerator-based BNCT for head and neck cancer (HNC). We investigated the correlation of ¹⁸F-BPA PET SUVmax and individual model doses with treatment response.

Materials and methods

We retrospectively analyzed 30 patients with HNC treated with accelerator-based BNCT (2020-2021). The Kaplan-Meier method was used for survival analysis. Dose parameters (Dmax, Dmin, and D80%) were calculate

SUBMITTER: Yoshino Y 

PROVIDER: S-EPMC13623982 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature