Analysis of the off-target interaction of amyloid PET tracers with human brain sulfotransferases.

ABSTRACT:

Background

Positron emission tomography (PET) tracers targeting amyloid-β (Aβ) are central to the diagnosis and staging of Alzheimer's disease (AD). However, growing evidence indicates that these tracers can engage off-target molecules, complicating signal interpretation. Sulfotransferases (SULTs) have been experimentally identified as binding partners of 11C-Pittsburgh Compound-B (PiB), but whether the clinically used fluorinated PiB derivatives interact with brain-expressed SULTs has not been explored.

Objective

To assess whether PiB and its fluorinated derivatives flutemetamol and flutafuranol interact with the SULT isoforms expressed in the human brain, and to characterize the structural features of these interactions.

Methods

We combined multi-omic transcriptomic

SUBMITTER: Miccoli L 

PROVIDER: S-EPMC13624043 | biostudies-literature | 2026 Sep

REPOSITORIES: biostudies-literature