Clinical Outcomes after Onset of Mirogabalin-Related Adverse Drug Reactions in Patients with Lumbar Spinal Stenosis: Post Hoc Analysis of the MiroTAS Study.

ABSTRACT:

Introduction

The MiroTAS study demonstrated the pain-relieving effect and safety of mirogabalin in patients with lumbar spinal stenosis (LSS); however, whether mirogabalin-related adverse drug reactions (mrADRs) affect clinical courses, treatment continuation, or adherence remained unknown. We examined recovery outcomes and treatment status following mrADR onset and whether the analgesic effects of mirogabalin correlated with LSS and leg pain durations.

Methods

This post hoc analysis of the 12-week, randomized controlled MiroTAS study summarized mrADRs (dizziness, somnolence, peripheral edema, and edema) by severity and outcome. Spearman's rank correlations between leg pain changes and duration of LSS and leg pain were examined.

Results

Data from 214 patients in the m

SUBMITTER: Nikaido T 

PROVIDER: S-EPMC13624239 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature