Geriatric 8 score predicts surgical risk and oncologic outcomes in older patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy.

ABSTRACT:

Background

Accurate preoperative risk stratification remains challenging in older patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU). This study evaluated whether preoperative Geriatric 8 (G8) score is associated with perioperative and oncologic outcomes.

Methods

We retrospectively analyzed 338 patients aged ≥ 65 years who underwent RNU between 2013 and 2022. Patients were classified as G8-low (score ≤ 14) or G8-high (score > 14). Multivariable logistic and Cox regression analyses assessed the association between frailty, postoperative complications (Clavien-Dindo classification), and survival outcomes, including overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS).

Results

Overall, 1

SUBMITTER: Lo CH 

PROVIDER: S-EPMC13625474 | biostudies-literature | 2026 Jul

REPOSITORIES: biostudies-literature