Maternal High-Fat Diet, During Preimplantation or Gestation/Lactation, Alters Mouse Offspring Metabolic, Molecular and Locomotor Phenotypes.

ABSTRACT: Maternal nutrition during offspring development influences the offspring physiology and risk of long-term chronic disease. Here, we investigate the effects of maternal high-fat diet during distinct developmental windows (preimplantation alone, EmbHFD; or throughout gestation and lactation, HFD) on adult offspring metabolic, molecular and motor behavioural outcome. Our mouse model, utilising healthy nonobese MF1 mothers, induced distinct offspring outcomes dependent upon dietary duration with some sex-specific effects. EmbHFD offspring had high serum leptin (females), elevated systolic blood pressure (SBP), low locomotory activity and diminished motor coordination. Similarly, HFD offspring not only had raised serum leptin, high SBP and poor motor coordination but also experienced excess wei

SUBMITTER: Peral-Sanchez I 

PROVIDER: S-EPMC13625825 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature