Disease phenotype affects treatment of late-onset inflammatory bowel disease: Analysis of a large UK cohort.

ABSTRACT:

Background

The incidence of inflammatory bowel disease (IBD) in older adults is rising. Studies of late-onset (LO) (diagnosis  ≥60 years of age) IBD are contradictory, with some suggesting increased use of corticosteroid and reduced use of advanced therapies. This multicenter study assessed disease phenotype and therapeutic choice in LO-IBD.

Methods

Patients recruited to the NIHR IBD BioResource with LO ulcerative colitis (UC) or Crohn's disease (CD) were compared with those with young-onset (YO) (16-39 years of age) and mid-onset (MO) (40-59 years of age) IBD. Medication use and surgeries were assessed in propensity score-matched cohorts.

Results

A total of 32 012 patients were studied: 16 930 UC (2247 LO) and 15 082 CD (1409 LO). LO-UC was mostly left-sided, with le

SUBMITTER: Foulser PFG 

PROVIDER: S-EPMC13626234 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature