Decomposing population differences in type 2 diabetes through a high-resolution GWAS of ~600,000 individuals with East Asian ancestry.

ABSTRACT: Type 2 diabetes (T2D) is a highly heterogeneous metabolic trait, with a higher prevalence in East Asians. Despite extensive genetic studies focusing mainly on Europeans, how genetic risk for T2D is distributed across biological pathways in East Asians in comparison with Europeans remains incompletely understood. Here, we show results from what is, to our knowledge, the largest genome-wide association study in East Asians, including 596,778 individuals, with a direct comparison to a European study of comparable sample size. We identified 196 loci, including three previously unreported loci. Subsequent multi-ancestry fine-mapping resolved 521 independent causal signals with high precision, revealing that 74% are shared while the remainder are strictly ancestry-specific. Beyond this shared ar

SUBMITTER: Saito K 

PROVIDER: S-EPMC13627662 | biostudies-literature | 2026 Sep

REPOSITORIES: biostudies-literature