An Anoikis-Related Gene Signature Associated With Stromal Remodeling and Clinical Outcome in Gastric Cancer.

ABSTRACT: Gastric cancer (GC) remains a highly aggressive malignancy with poor prognosis. Anoikis resistance is closely associated with tumor progression and metastasis, but the prognostic and functional relevance of anoikis-related genes (ARGs) in GC remains incompletely understood. Public transcriptomic, clinical, somatic mutation, and single-cell RNA sequencing (scRNA-seq) datasets were integrated to identify differentially expressed ARGs, develop an ARG-based risk model, and investigate its associations with tumor microenvironment (TME) features. In vitro experiments were performed to assess the effects of selected candidate genes on GC cell migration and invasion. Forty-five differentially expressed ARGs were identified in The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD) cohort. An AR

SUBMITTER: Fu Z 

PROVIDER: S-EPMC13627849 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature