Maternal cardiac risk stratification in contemporary practice: external validation of mWHO, CARPREG II and ZAHARA in a 14-year tertiary cohort.

ABSTRACT:

Background

Pregnancy in women with cardiac disease carries substantial maternal risk. The modified WHO classification, Cardiac Disease in Pregnancy Study II (CARPREG II) and Zwangerschap bij Aangeboren HARtAfwijkingen (ZAHARA; Pregnancy in Congenital Heart Disease) are the three principal risk stratification tools in this setting. External validation in contemporary practice is essential to assess its performance in specialist programmes.

Methods

Single-centre retrospective cohort study of all pregnancies in women with cardiac disease delivering ≥24+0 gestational weeks at a level IV maternal centre between 2009 and 2023. The primary outcome was maternal cardiac complication within 12 months postpartum; the secondary outcome was obstetric complication during pregnancy or the

SUBMITTER: Houri O 

PROVIDER: S-EPMC13629931 | biostudies-literature | 2026 Sep

REPOSITORIES: biostudies-literature