Umbilical Cord Quantitative Polymerase Chain Reaction and Sepsis Complications for Neonates.

ABSTRACT:

Importance

Sepsis occurring in the first 72 hours of life is associated with high mortality and complications such as intraventricular hemorrhage (IVH), particularly in preterm infants. Although blood culture is the diagnostic standard, its low detection rate may underestimate the clinical burden of infection.

Objective

To determine whether molecular detection of bacterial DNA in umbilical cord tissue improves identification of preterm infants at risk of sepsis-related death or grade IV IVH.

Design, setting, and participants

Samples were collected from infants with a birth weight less than 1500 g between January 2009 and December 2021 in a research network of level 3 neonatal intensive care units (67 sites) and were analyzed by using multiplex quantitative polymerase

SUBMITTER: Hanenberg L 

PROVIDER: S-EPMC13631874 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature