Untargeted metabolomics reveals remodeling of hepatic metabolic networks and potential tumor-associated metabolic signatures induced by ALV-J in Luhua chickens.

ABSTRACT: Avian leukosis virus subgroup J (ALV-J) represents a major pathogen that severely threatens the poultry industry. The liver contains abundant sinusoidal blood vessels with slow blood flow, which facilitates the enrichment and replication of viral particles; it serves as the primary target organ of ALV-J and the site with the highest tumor incidence. Nevertheless, the hepatic metabolic alterations triggered during ALV-J infection and their potential links to disease progression remain poorly understood. This study aimed to characterize the hepatic metabolic remodeling profile of Luhua chickens upon ALV-J infection using untargeted metabolomics. One-day-old Luhua chickens were divided into an ALV-J-infected group and a control group. Liver tissues were harvested at 60 days post-infection (dp

SUBMITTER: Wang Y 

PROVIDER: S-EPMC13631893 | biostudies-literature | 2026 Sep

REPOSITORIES: biostudies-literature