SERPINE1 promoter variants and differential airway responses to virus and biological therapy.

ABSTRACT:

Background

A common functional promoter polymorphism (4G4G/4G5G) in the SERPINE1 gene, which encodes the plasminogen activator inhibitor 1 (PAI-1) protein, is associated with more frequent asthma exacerbations.

Objective

We examined genotype-specific airway transcriptomic responses during viral illness and how genotype modulates these responses in asthma exacerbations with and without mepolizumab treatment.

Methods

Nasal lavage samples from a subset of children aged 6-17 years with exacerbation-prone asthma from the type 2-enriched urban asthma MUPPITS-1 and MUPPITS-2 cohorts were used for RNA sequencing and genetic studies. Expression quantitative trait locus (eQTL) analysis and weighted gene coexpression network analysis were performed to determine PAI-1 genotype mo

SUBMITTER: Thames AH 

PROVIDER: S-EPMC13632648 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature