Defect-engineered lignite-derived carbon/NiCo₂O₄ interfaces enable oxygen-vacancy-mediated nonenzymatic glucose sensing in serum samples.

ABSTRACT: The development of robust materials for nonenzymatic glucose sensing remains challenging due to material cost, instability, and limited mechanistic understanding. Moreover, many existing reports lack validation using real samples, making their real-world applicability uncertain. We report a novel defect-engineered interface composed of spinel nickel cobalt oxide and lignite-derived porous carbon (NCO/LC). The engineered carbon-oxide interface induces oxygen-vacancy-rich active sites, promoting rapid redox kinetics and electrocatalytic glucose oxidation. Initial electrochemical characterization was performed using a glassy carbon electrode (GCE) to establish the sensing mechanism, followed by successful translation to a screen-printed electrode (SPE) for practical validation and real sample

SUBMITTER: Faruk S 

PROVIDER: S-EPMC13632827 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature