Local field potential biomarkers for adaptive deep brain stimulation in Parkinson's disease: A scoping review.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly. Conventionally, to combat the symptoms, drugs such as Levodopa and conventional deep brain stimulation (DBS) are routinely used. However, with time, the efficiency of both treatment modalities wears off and accompany side effects. Advocating for the need to explore subsequent management options such as adaptive DBS (aDBS) - a tailor-made DBS promising more personalized and favorable outcomes. The main objective of this review was to explore local field potentials (LFPs) as biomarkers for aDBS in PD. In addition, to investigate any correlations between the LFPs biomarkers, their physiology, and how they affect the quality of aDBS.

Methods

A literature search was conducted

SUBMITTER: Khan RA 

PROVIDER: S-EPMC13633525 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature