Exercise alleviates age-related osteoarthritis associated with PGC-1α activation to suppress chondrocyte senescence and aberrant glycolysis.

ABSTRACT: Age-related osteoarthritis (OA) is a leading global disability cause. Exercise is recommended as first-line therapy but poorly tolerated by elderly patients. This study elucidated the mechanism of low-intensity exercise in OA and develop a targeted exercise-mimetic nanotherapy. The effects of low-intensity swimming exercise on age-related OA were investigated using aged mouse models. A senescence-targeted nanoparticle system (NP-B2M) was fabricated via a double-emulsion solvent evaporation method combined with EDC/NHS conjugation. The mechanisms underlying exercise and PGC-1α-mediated metabolic reprogramming were explored using transcriptomic sequencing, glycolysis analysis, RT-qPCR, and Western blotting in IL-1β-induced senescent ATDC5 chondrocytes. The therapeutic efficacy of intra-artic

SUBMITTER: Cao Y 

PROVIDER: S-EPMC13634101 | biostudies-literature | 2026 Sep

REPOSITORIES: biostudies-literature