Ambient intelligence-based framework for quantitative evaluation of cell culture operations to support standardization and training.

ABSTRACT: The widespread implementation of cell therapy has increased the demand for stable and reproducible cell manufacturing methods. However, many cell manufacturing processes rely heavily on manual cell culture operations, and operator training remains largely dependent on subjective assessment and tacit knowledge. This limits the establishment of training targets and hinders operational standardization. Recent advances in ambient intelligence have created new opportunities for digitizing human work processes and supporting their quantitative evaluation. In this study, we developed an ambient intelligence-based framework for digitizing, visualizing, and quantitatively comparing manual cell culture operations. A defined mock seeding operation was performed by one expert with 10 years of cell cul

SUBMITTER: Momose K 

PROVIDER: S-EPMC13634541 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature