Dedifferentiation in endometrial cancer is associated with HLA-I silencing that may be restored by IFN-γ.

ABSTRACT: Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low-grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protein(s). This typically occurs in a microsatellite-instable molecular context. This study aims to identify the immune evasion mechanisms associated with dedifferentiation. Whole-slide immunohistochemistry-based image analysis was used to compare spatial cancer immunophenotypes and human leukocyte antigen class I (HLA-I) expression between the differentiated and undifferentiated components of 14 SWI/SNF-inactivated dedifferentiated endometrial carcinomas. Flow cytometry and in vivo xenograft studies were performed to gain functiona

SUBMITTER: De Leo A 

PROVIDER: S-EPMC13635600 | biostudies-literature | 2026 Jul

REPOSITORIES: biostudies-literature