Investigating the influence of maternal prenatal BMI and perinatal depressive symptoms on neonatal brain network dynamics.

ABSTRACT:

Background

Elevated pre-pregnancy body mass index (BMI) and perinatal depressive symptoms have been linked to neonatal alterations in brain structure and function. This study examined associations between neonatal functional brain dynamics, maternal BMI, and perinatal depressive symptoms measured by the Edinburgh Postnatal Depression Scale (EPDS) in a community-based, largely low-risk cohort.

Methods

Funcitonal MRI and Leading Eigenvector Analysis (LEiDA) were applied in a neonatal cohort (N = 437; 236 males; mean gestational age 39.6 weeks) from the developing Human Connectome Project. We assessed whether neonatal brain-state probabilities related to maternal BMI and EPDS scores (M = 5.6, SD = 4.3), testing main effects and, separately, their interaction. The sample include

SUBMITTER: Mariani Wigley ILC 

PROVIDER: S-EPMC13638477 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature