Lifestyle for Brain health (LIBRA) score, cognition, brain volume, and dementia risk in the UK Biobank.

ABSTRACT: A substantial proportion of dementia risk may be attributable to modifiable factors, yet these are often examined in isolation despite their interrelated nature and tendency to co-occur. It remains unclear whether the relationship between modifiable factors and dementia risk is influenced by individual characteristics such as sex and genetic susceptibility. We investigated longitudinal associations between the Lifestyle for Brain health (LIBRA) score and risk of dementia, cognitive performance, and brain structure, and whether relationships differed by sex and APOE ɛ4 carrier status.Participants were aged > 50 years, dementia-free at baseline, 50% female and predominantly (97%) white/Caucasian. The LIBRA score included 11 modifiable factors (e.g., hypertension, obesity, physical inactivity

SUBMITTER: Sewell KR 

PROVIDER: S-EPMC13638863 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature