Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the effects of hepatitis B vaccine and immunoglobulin in newborn infants of mothers positive for hepatitis B surface antigen.

Design

Systematic review and meta-analysis of randomised clinical trials.

Data sources

Electronic databases and hand searches.

Review methods

Randomised clinical trials were assessed for methodological quality. Meta-analysis was undertaken on three outcomes: the relative risks of hepatitis B occurrence, antibody levels to hepatitis B surface antigen, and adverse events.

Results

29 randomised clinical trials were identified, five of which were considered high quality. Only three trials reported inclusion of mothers negative for hepatitis B e antigen. Compared with placebo or no intervention, vaccination reduce

SUBMITTER: Lee C 

PROVIDER: S-EPMC1363909 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature