Vitamin D levels and skeletal quality of life in adult Langerhans cell histiocytosis.

ABSTRACT:

Objective

This study aims to prospectively evaluate the association between vitamin D optimization and quality of life (QoL) and bone metabolism in adult patients with Langerhans cell histiocytosis (LCH).

Design and methods

In this prospective, uncontrolled, observational study, 45 adult LCH patients received individualized cholecalciferol supplementation for 3 months to achieve serum 25-hydroxyvitamin D (25(OH)D) levels ≥30 ng/mL. Skeletal-related and general QoL were assessed using the QUALEFFO-41 and SF-36 questionnaires, respectively. Biochemical markers of calcium metabolism and bone turnover were measured at baseline and follow-up. Correlation and exploratory linear regression analyses evaluated associations between changes in parameters.

Results

Levels of 25(OH

SUBMITTER: Gravvanis C 

PROVIDER: S-EPMC13641142 | biostudies-literature | 2026 Sep

REPOSITORIES: biostudies-literature