Metrnl Reduces Thrombosis and Acute Myocardial Injury Through Inhibition of Platelet Activation via CD36 Receptor Degradation.

ABSTRACT:

Background

Metrnl (Meteorin-like) is a secreted protein that plays a pivotal role in regulating insulin sensitivity, angiogenesis, and atherosclerosis. The circulating Metrnl levels are mainly derived from the endothelium and associated with atherosclerosis and arterial thrombotic disease in patients. However, Metrnl effects on platelets and thrombosis are not yet fully understood.

Methods

By using global Metrnl knockout mice, platelet-specific Metrnl knockout mice, recombinant Metrnl protein, and Metrnl-neutralizing antibody, combined with visualization techniques, we investigated the effects of Metrnl on human and rodent platelet activation in vitro, and thrombosis in vivo as well as its action mode. To screen and verify receptor-mediated mechanisms for Metrnl, we used imm

SUBMITTER: Miao ZW 

PROVIDER: S-EPMC13641263 | biostudies-literature | 2026 Aug

REPOSITORIES: biostudies-literature