Effects of high-molecular-weight hyaluronic acid on inflammatory and matrix-associated responses in a chondrocyte-osteoclast co-culture model.

ABSTRACT:

Background

Osteoarthritis (OA) is a degenerative joint disorder marked by chronic inflammation, extracellular matrix (ECM) breakdown, and subchondral bone remodeling, ultimately leading to loss of cartilage integrity and joint function. Hyaluronic acid (HA), a key component of synovial fluid, contributes to joint lubrication and has been implicated in the regulation of inflammatory and anabolic processes. High-molecular-weight (HMW) HA (> 1 MDa) is reported to exert anti-inflammatory and matrix-preserving effects; however, its role in multicellular systems remains incompletely understood. In this study, we investigated the effects of HMW HA using an in vitro chondrocyte-osteoclast co-culture model designed to reflect key features of the osteoarthritic microenvironment.

Methods</

SUBMITTER: Eid A 

PROVIDER: S-EPMC13644255 | biostudies-literature | 2026 Jul

REPOSITORIES: biostudies-literature