Effect of Hyaluronic Acid on Palatal Wound Healing-A Randomized Crossover Clinical Trial.

ABSTRACT:

Aim

To assess the effect of a hyaluronic acid (HyA) containing gel on patient-related outcomes (PRO) and wound healing after palatal punch-biopsy representing a free gingival graft.

Material and methods

A punch-biopsy (6 mm diameter, 2 mm thickness) was harvested from one side of the palate at Day 0 and from the contralateral side at Day 21. Sites were randomly allocated to either 0.3% HyA containing gel (test) or sterile saline solution (control), professionally applied after harvesting and then self-applied three times/day for 7 days. Up to 21 days PRO-related questionnaires were answered and intraoral scans and photographs recorded to assess wound re-epithelialization, tissue refill, and color match.

Results

Eighteen of 25 recruited participants were analyzed. Pain

SUBMITTER: Dahi M 

PROVIDER: S-EPMC13644540 | biostudies-literature | 2026 Jul

REPOSITORIES: biostudies-literature