Increased activity of DRD1-MSNs in dorsolateral striatum underlies Cry1Δ11 mutation-induced repetitive behaviors.

ABSTRACT: Repetitive behaviors are classically associated with autism spectrum disorder and obsessive compulsive disorder, but also occur prominently in attention-deficit/hyperactivity disorder (ADHD), yet the underlying mechanisms remain poorly understood. Our recent work identified ADHD-like behaviors in Cry1Δ11 mice, in which a mutation in a core circadian gene Cry1 produces a CRY1Δ11 protein that fails to inhibit the Gαs subunit, leading to hyperactive signaling of dopamine D1 receptor (DRD1). Although this dysregulation was initially reported in the ventral striatum, we hypothesized that similar mechanisms might be present in the dorsal striatum, a brain region critically involved in the generation of repetitive behaviors and densely populated by DRD1-expressing medium spiny neurons (MSNs). Her

SUBMITTER: Liu X 

PROVIDER: S-EPMC13645795 | biostudies-literature | 2026 Jul

REPOSITORIES: biostudies-literature