Vaccination in pediatric transplantation-General recommendations. A position paper by the European Reference Network TransplantChild.

ABSTRACT: Infectious diseases remain a leading cause of morbidity and mortality among pediatric transplant recipients, despite significant advances in transplantation management. Vaccination is the most effective strategy to prevent infections; however, its efficacy is hindered in solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients, due to altered immune responses. Pediatric SOT candidates often have incomplete vaccination status prior to transplantation and reduced vaccine efficacy post-transplant due to immunosuppressive therapy. They are also at greater risk of vaccine-preventable infections compared to adults, leading to higher rates of hospitalization, graft loss, and death. In HSCT recipients, immune ablation and reconstitution result in the loss of immunologi

SUBMITTER: Casotti V 

PROVIDER: S-EPMC13646023 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature