First identification of an amphibian-derived peptide with anti-vascular aging activity.

ABSTRACT: Vascular aging is a principal driver of cardiovascular morbidity and mortality, and effective prevention of age-related vascular pathologies depends on interventions that target fundamental molecular and cellular aging pathways. The present study investigated the anti-vascular aging activity of AL-VI10, a novel bioactive peptide derived from amphibian skin, together with the underlying mechanism. Notably, AL-VI10 exhibited excellent biosafety, with no detectable cytotoxic or hemolytic activity, and showed potent free radical scavenging capacity, enhanced antioxidant enzyme activity, and reduced reactive oxygen species (ROS) accumulation. In a D-galactose-induced mouse model of aging, AL-VI10 significantly attenuated vascular aging-associated phenotypes, including increased medial thickness

SUBMITTER: Liu X 

PROVIDER: S-EPMC13647062 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature