Cost-effectiveness of concurrently available oral and long-acting injectable pre-exposure prophylaxis for preventing HIV infections among men who have sex with men in eastern China: A modelling study.

ABSTRACT:

Background

China faces a growing HIV burden among men who have sex with men (MSM), yet uptake of pre-exposure prophylaxis (PrEP) remains low. Long-acting injectable cabotegravir (CAB-LA) may improve prevention effectiveness, but its economic value in China remains uncertain.

Methods

We developed a risk-stratified dynamic compartmental model incorporating HIV natural history, diagnosis, ART, and both transmitted and acquired drug resistance. Model parameters were calibrated to published surveillance data in Zhejiang and Jiangsu Province from 2009 to 2019. Assuming zero PrEP coverage in 2025, we simulated scale-up among high-risk MSM through 2030 under six scenarios: no PrEP (status quo); 20%, 50%, and 80% oral PrEP only; and total PrEP coverage of 80% with CAB-LA comprising 2

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC13647645 | biostudies-literature | 2026 Jul

REPOSITORIES: biostudies-literature